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KMID : 0362720150530010028
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Journal of the Korean Dental Association
2015 Volume.53 No. 1 p.28 ~ p.35
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Bone regeneration in oral and maxillofacial field using rhBMP-2
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Hwang Soon-Jung
Park Min-Woo
Park Jae-Bong
Park Hyun-Soo
Paek Seung-Jun
Sul Hee-Kyung
Lee Kyung-Jin
Hong Dong-Hwan
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Abstract
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To overcome shortcoming of autogeneous, allogenic, xenogenic and alloplastic bone grafts, various growth factors related to bone regeneration have been identified and developed. Among them, rhBMP-2 is regarded as the most potent osteoinductive growth factor and it can trigger the differentiation of mesenchymal stem cells to osteogenic cells for accelerated new bone formation And several commercial products of rhBMP-2 are available in Korea. It is applied to maxillary sinus augmentation, guided bone regeneration and preservation of extraction socket. In this review, the development, action mechanism and clinical applications of rhBMP-2 will be described.
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KEYWORD
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rhBMP-2, carrier, alveolar bone, oral and maxillofacial bone regeneration
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